Dame Shirley may refer to:
British title DBE Dame Shirley Bassey (born 1937), Welsh singer Dame Shirley Conran (1932–2024), British designer, writer, entrepreneur Dame Shirley Paget (1924–2017), public servant, writer, marchioness Dame Shirley Pearce (born 1954), British academic and psychologist Dame Shirley Porter (born 1930), British politician, Tesco heiress Dame Stephanie Shirley, British information technology pioneer, businesswoman and philanthropist
Pen name Louise Clappe (1819–1906), American writer, used pen name "Dame Shirley" for her "Shirley letters"