Devil's Highway or The Devil's Highway may refer to:
Roads Devil's Highway (New Mexico) or U.S. Route 491, from its former designation as U.S. Route 666 New Mexico, Colorado and Utah (USA) Devil's Highway (Roman Britain), the Roman road from Londinium (London) to Calleva Atrebatum (Silchester) Devil's Highway (Sonora), also called El Camino del Diablo, a prehistoric and colonial trail through the Sonora Desert in Arizona (USA) and Sonora (Mexico) Route A666 in England, nicknamed the "Devil's Highway" both because of the number 666 and the road's high accident rate
Arts entertainment, and media Devil's Highway (film), a 2005 horror film directed by Fabien Pruvot The Devil's Highway: A True Story (2004), Luís Alberto Urrea's non-fiction book that describes the May 2001 attempt of 26 men to cross the Mexican border into the US through the southern Arizona desert, a region known as the Devil's Highway
See also Devil's Causeway, the Roman Road along Hadrian's Wall