Cacique is a Native American title for a chief or leader; in the modern era in Spanish America, Brazil, Spain and Portugal a political boss or leader generally

Cacique may also refer to:

Cacique (bird), several species Cacique (horse) Cacique (rum), from Venezuela Cacique Guaro, a brand of alcohol from Costa Rica Cacique, Colón, a subdivision of the Colón Province, Panama Cacique, Distrito Nacional, a sector of Santo Domingo, Dominican Republic Cacique, a lingerie brand by Lane Bryant

See also Cassique, a proposed title for American nobility Cacique Nutibara Bloc, a Colombian paramilitary bloc Estadio Cacique Diriangén, a stadium