major histocompatibility complex (human), class I, B53 Alleles B*5301 B*5302 Structure (See HLA-B) Symbol(s) HLA-B EBI-HLA B*5301 EBI-HLA B*5302 Locus chr.6 6p21.31
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)
Serotype + B53 and B35 serotype recognition of Some HLA B*35 allele-group gene productsderived from IMGT/HLA B*53 B53 B35 Sample allele % % size (N) 5301 86 5 3054 5302 80 20 5
B*5301 allele frequencies + HLA B*7801 frequencies freq ref. Population (%) Akan Adiopodoume (Ivory Coast)22.7 Rimaibe (Burkina Faso)22.3 Mossi (Burkina Faso) 20.8 Bandiagara (Mali) 15.9 Sawa (Cameroon)11.5 Lusaka (Zambia) 10.2 Baka Pygmy (Cameroon) 10.0 Guinea Bissau10.0 Harare Shona (Zimbabwe)9.3 Baloch (Iran) 9.1 Kenya 8.7 Canoncito Navajo (USA)8.5 Brahui (Pakistan)7.7 Niokholo Mandenka (Senegal)5.3 Croatia (2)5.0 Mongolia Khoton Tarialan4.9 Pakistan Baloch4.6 Casablanca (Morocco)3.7 Arratia Basque (Spain) 3.3 Crete (Greece)3.2 Israel Arab Druse2.5 Israel Gaza Palestinians2.4 Amman (Jordan )2.4 Tunis (Tunisia )2.3 Tuva (2) (Russia)2.2 Oman2.1 France South East1.6 Saudi Arabia Guraiat and Hail1.5 Berber (Morocco)1.4 Georgia Svaneti Svans1.3 Mongolia Khalkh Ulaanbaatar1.2 Spain Catalonia Girona1.1 India Andhra Pradesh Golla1.0 Mongolia Khalha1.0
Haplotype frequencies + A*3601 : Cw*0401 : B*5301 freq ref. Population (%) Zimbabwe3.6 Zambia Lusaka2.3 N. Afr. Negroid 2.1 Kenya Luo1.9 Cameroon Yaounde1.7 African American1.5 Kenya Nandi1.3 American Hispanic0.2 ' A*6802 : Cw*0401 : B*5301 Mali Bandihagara2.7 African American1.4 Kenya Nandi1.0 Hispanic American 0.6 Caucasian American 0.2
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.
References