Sweet Lou may refer to:
Sweet Lou (album), a 1974 album by jazz saxophonist Lou Donaldson Sweet Lou (horse) (foaled 2009)
People with the nickname Lou Amundson (born 1982), former NBA basketball player Lou Hudson (1944–2014), former All-Star basketball player Louis Dunbar (born 1953), basketball player for the Harlem Globetrotters Lou Johnson (1934–2020), Major League Baseball player Lou Piniella (born 1943), Major League Baseball manager and player Lou Williams (born 1986), NBA basketball player Lou Whitaker (born 1957), Major League Baseball player Lou Singer, a main character in the 2003 movie Grind