Marie-Odile is a French feminine given name, composed of Marie and Odile. It may refer to:
Marie Odile Bonkoungou-Balima (born 1961), Burkinabé ambassador Marie-Odile Bouillé (born 1950), French politician Marie-Odile Cordier (born 1950), French computer scientist Marie-Odile Marceau, Canadian architect Marie-Odile Raymond (born 1973), Canadian cross-country skier Marie-Odile Soyer-Gobillard (born 1939), French biologist a character in the 1998 film Madeline