Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used as a derivatizing agent to measure levels of amines and amino acids. The reagent reacts with them in alkaline solution to produce a fluorescent material that can be easily detected.
This should not be confused with Folin-Ciocalteu reagent, that is used to detect phenolic compounds.
The Folin reagent can be used with an acidic secondary reagent to distinguish MDMA and related compounds from PMMA and related compounds. Substance Reaction MDMA Pink MDE No Reaction MDA Yellow BZP Orange to red TFMPP Pinkish red Methylone No reaction Methamphetamine Pink Amphetamine Light orange PMA Light Yellow PMMA Light orange Ketamine No reaction Mescaline No reaction Cocaine No reaction Aspirin No reaction Sugar No reaction
See also Dille–Koppanyi reagent Froehde reagent Liebermann reagent Mandelin reagent Marquis reagent Mecke reagent Pill testing Simon's reagent Sullivan reaction Zwikker reagent
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