Trafficante may refer to:
Trafficante crime family, mafia crime family in the state of Florida. Santo Trafficante Sr. (1886–1954) Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr. Santo Trafficante Jr. (1914–1987) Powerful Tampa, Florida-born mobster, son of mobster Santo Trafficante Sr.
See also James Traficant (19412014), U.S. Representative from Ohio