Great Central or Great Central Railway may refer to:
Railways Great Central Railway, a historical railway company in the United Kingdom Great Central Railway (heritage railway), a modern heritage railway in Leicestershire, England Great Central Railway (Nottingham), a modern heritage railway in Nottinghamshire, England Great Central Main Line, the historical route these companies follow(ed) Great Lakes Central Railroad, a short line in Michigan, United States Great Western and Great Central Joint Railway, a main line in south east England Hull and Barnsley and Great Central Joint Railway, also known as the Gowdall and Braithwell Railway Great Central tube station, the former name of Marylebone London Underground station, in England
Other Great Central Lake, lake in British Columbia, Canada Great Central League, baseball league in the Upper Midwest United States Great Central Mines, a defunct mining company in Australian Great Central Road, in Australia
See also Grand Central (disambiguation)