Perona is a surname. Notable people with the surname include:
Bernard Perona, American author Joaquín Navarro Perona (1921–2002), Spanish footballer John Perona, Italian-American nightclub owner Pietro Perona, Italian-American engineering professor, co-author of anisotropic diffusion Renato Perona, Italian cyclist
See also Perona, a character in One Piece 8230 Perona, an asteroid