PFL may refer to:
Sport Professional Fighters League, an American mixed martial arts league Peel Football League, an Australian rules football league Pioneer Football League, an NCAA Division I FCS football conference Professional Futsal League, an American sports league Philippines Football League, an association football league in the Philippines Polish Football League, an American football league in Poland
Professional Football League First Professional Football League (Bulgaria) Professional Football League of Ukraine Russian Professional Football League TT Pro League, formerly the Professional Football League of Trinidad and Tobago Uzbekistan Super League
Science Pyruvate formate lyase, an enzyme important in the regulation of anaerobic glucose metabolism Positive feedback loop
Language PFL, ISO 639-3 language code for the Palatine German language People-first language
Organisations Perth Freight Link, transport route for trucks to access Fremantle port starting at Muchea in Western Australia. Pacific Forum Line, a shipping alliance located in Nauru Partido da Frente Liberal (Liberal Front Party), a Brazilian political party Popular Front of Latvia, a former Latvian political party Priests for Life, an American-based Roman Catholic anti-abortion organization
Other Paid Family Leave (California), a California law that extends unemployment disability compensation Pre-fader listen, a sound mixer function used for making a Fade (audio engineering) Purfleet railway station, Thurrock, Essex, England (National Rail station code PFL)