OTR or Otr may refer to:
Arts and entertainment Off the Record with Michael Landsberg, a sports talk show Old-time radio, a broadcasting era Otierre, an Italian hip hop band
Science and technology Ocular tilt reaction, a form of skew deviation involving the anatomy of the inner ear Off-the-Record Messaging, an instant messaging encryption protocol Oxygen transmission rate, of a substance × Otaara, a plant genus
Other uses Occupational Therapist, Registered, Licensed Ótr, a mythical dwarf OTR, IATA code for Coto 47 Airport, in Costa Rica OTR (convenience store), Australian petrol and convenience store chain Over the road, truck drivers without schedule or route Over-the-Rhine, a neighborhood in Cincinnati, Ohio, US Public Television of Russia (OTR), a Russian television channel