Joe Louis (1914–1981) was an American world heavyweight boxing champion.

Joe Louis may also refer to:

Joe Louis (puppeteer) (Sakorn Yang-keawsot, 1922–2007), Thai dancer and puppeteer Joe Louis (horse), a horse owned by the United States Army Joe Hill Louis (1921–1957), American musician

See also Joe Louis Arena in Detroit Jos Louis, chocolate pastry Joe Lewis (disambiguation) Joseph Lewis (disambiguation)