Leguizamón is a surname. Notable people with the surname include:
Aníbal Leguizamón (born 1992), Argentine footballer Baltazar Leguizamón (born 2000), Argentine racing driver Iván Leguizamón (born 2002), Paraguayan footballer Jimena Leguizamón (born 2005), Colombian swimmer José Leguizamón (born 1991), Paraguayan footballer Juan Manuel Leguizamón (born 1983), Argentine rugby player Leandro Leguizamón (born 1988), Argentine footballer Luciano Leguizamón (born 1982), Argentine footballer Luis Lezama Leguizamón Sagarminaga (1865–1933), Spanish industrialist and politician Manuel Lezama Leguizamón Sagarminaga (1862–1924), Spanish industrialist and politician María Leguizamón (born 1965), Argentine politician Mario Leguizamón (born 1982), Uruguayan footballer Martiniano Leguizamón (1858–1935), Argentine lawyer and writer Nicolás Leguizamón (born 1995), Argentine footballer Oscar Leguizamón (born 1966), Argentine footballer Pablo Leguizamón Arce (born 1982), Paraguayan footballer Sonia Álvarez Leguizamón (born 1954), Argentine sociologist and anthropologist Victoriano Leguizamón (1922–2007), Paraguayan footballer