San Cebrián de Mazote is a municipality located in the province of Valladolid, Castile and León, Spain.
According to the 2004 census (INE), the municipality had a population of 200 inhabitants.
The village has a medieval church dedicated to a saint known as Cipriano or Cebrián (Cyprian in English). The architecture has been described as Mozarabic or Repoblación.
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