Izotov (masculine, ) or Izotova (feminine, ) is a Russian surname. Notable people with the surname include:
Danila Izotov (born 1991), Russian swimmer Dmitry Izotov (born 1984), Russian soccer player Eduard Izotov (1936–2003), Soviet actor Eugene Izotov (born 1973), Russian oboist Nikita Izotov (1902–1951), Soviet mine worker Sergei Izotov (1917–1983), Soviet aircraft engine designer