Longino is an Italian surname. Notable people with the surname include:

Andrew H. Longino (1854–1942), Governor of Mississippi Andrew Longino (freestyle skier) (born 2002), Canadian freestyle skier Helen Longino (born 1944), American philosopher Jordan Longino (born 2002), American basketballer

See also Longino Welch (1900–1969), American track and field athlete Dr. H.A. Longino House, historic building in Arkansas Longinos, name