As of Big Brother 28, a total of 381 participants have competed in Big Brother, Big Brother: Over the Top, and Big Brother: Reindeer Games and 46 of them have competed in multiple seasons. A total of 34 participants have competed in Celebrity Big Brother, which increases the total number of Big Brother participants to 415. Big Brother 7 was an All-Star edition, which featured 14 returning HouseGuests chosen either through viewer vote or by producers from an initial group of 20 candidates. For Big Brother 11, four past HouseGuests were given the chance to return based on the results of the season's first competition, after which one of them entered the house. Big Brother 13 featured three "Dynamic Duos" from previous seasons, Big Brother 14 brought in four Big Brother veterans to coach the 12 new HouseGuests and Big Brother 18 saw the return of four returnees playing the game with 12 new HouseGuests. In Big Brother: Over the Top, former HouseGuests Jason Roy and Jozea Flores were given the chance to return through a public vote. Roy won the public vote and became the 13th HouseGuest. Big Brother 19 brought along the return of a past HouseGuest as the 17th HouseGuest, but that HouseGuest was actually there to take the spot of one of the 16 new HouseGuests, as a consequence for one of the newbies taking a temptation. Big Brother 22 was another All-Star edition, featuring 16 returning HouseGuests, all chosen by production. Big Brother: Reindeer Games was a special holiday themed "Legends" edition, with 9 returning HouseGuests, as well as 3 other former HouseGuests participating solely as hosts. Big Brother 27 and Big Brother 28 brought along the return of a past HouseGuest as a surprise HouseGuest.

While locked inside the House, the HouseGuests are free to leave the game for any unforeseen reason ("Walking"), though they will not be allowed re-entry; as of September 2022, only four HouseGuests have left the game over the course of its history. Although this has rarely occurred, should any of the HouseGuests break the rules of the game, they are immediately removed from the House ("Getting expelled") and barred from return; as of November 2023, only five expulsions have occurred throughout the history of the show.

Key legend

Seasons 1–10 (2000–2008)

Name Age HometownProfession Season Status Finish William Collins27 PoliticianBig Brother 1 Jean Jordan26 Exotic dancer Karen Fowler43 Mother Brittany Petros25 Actress Cassandra Waldon37 UN communications director George "Chicken" Boswell41 Roofer Jamie Kern22 Model Curtis Kin28 Lawyer Joshua Souza23 Civil engineering student Eddie McGee21 Entertainment industry Justin Sebik26 BartenderBig Brother 2 Sheryl Braxton43 Interior decorator Autumn Daly28 Aspiring singer Shannon Dragoo29 Real estate agent Mike "Boogie" Malin30 Bar owner Kent Blackwelder46 Mortgage broker Krista Stegall28 Waitress Bill "Bunky" Miller36 Technical writer Hardy Ames-Hill31 Account executive Monica Bailey40 Candy store manager Nicole Nilson Schaffrich31 Personal chef Will Kirby28 Physician Lori Olsen39 Bank representativeBig Brother 3 Tonya Paoni35 Retail sales Eric Ouellette27 Firefighter Josh Feinberg28 Waiter Chiara Jude Berti25 Marketing representative Gerald "Gerry" Lancaster51 Teacher Roddy Mancuso30 Writer Marcellas Reynolds32 Fashion stylist Amy Crews23 Real estate appraiser Jason Guy25 Videographer Danielle Reyes30 Media buyer Lisa Donahue26 Bartender Scott Weintraub33 WaiterBig Brother 4 Amanda Craig25 Bar manager Michelle Maradie19 Student David Lane21 Former Army Ranger Dana Varela28 Karate school manager Nathan Marlow23 Personal trainer Justin Giovinco22 Pittsburgh, PA Headhunter Jack Owens Jr.58 Former FBI agent Jee Choe23 Elmhurst, NY Bookkeeper Erika Landin33 Pilates instructor Robert Roman33 Restaurant manager Alison Irwin22 Retail sales manager Jun Song27 Investment manager Mike Lubinski41 Commercial painterBig Brother 5 Lori Valenti26 Yoga instructor Holly King27 Model Scott Long25 Pittsburgh, PA Sales representative Jason "Jase" Wirey28 Volunteer firefighter Will Wikle26 Registered nurse Natalie Carroll30 Fitness professional Adria Klein30 Fitness professional Marvin Latimer36 Mortician Karen Ann (O'Neil) Ganci30 Portrait artist Jennifer "Nakomis" Dedmon21 Restaurant hostess Diane Henry22 Cocktail waitress Michael "Cowboy" Ellis23 Security officer Drew Daniel22 College graduate Ashlea Evans22 Fashion design studentBig Brother 6 Michael Donnellan28 Artist Eric "Cappy" Littmann36 Firefighter Sarah Hrejsa23 Retail manager Kaysar Ridha24 Graphic designer Jennifer Vasquez27 Arena Football League dancer Rachel Plencner33 Horse breeder James Rhine29 Loss prevention manager Beau Beasley25 Personal shopper Howie Gordon34 Meteorology student April Lewis31 Pharmaceutical sales representative Janelle Pierzina25 VIP cocktail waitress Ivette Corredero25 Waitress Maggie Ausburn27 Emergency room nurse Alison Irwin ^25Medical salesBig Brother 7(All-Stars) Jennifer "Nakomis" Dedmon ^23 Restaurant host Jason "Jase" Wirey ^30 Safety director Diane Henry ^24 Model/actress Kaysar Ridha ^25 Graphic designer Marcellas Reynolds ^36 Celebrity stylist Howie Gordon ^35 Lightsaber salesman James Rhine ^30 Loss prevention manager Danielle Reyes ^34 Property manager George "Chicken" Boswell ^47 Hotel promotions Will Kirby ^33 Physician Janelle Pierzina ^26 VIP cocktail waitress Erika Landin ^36 Pilates instructor Mike "Boogie" Malin ^35 Restaurateur Carol Journey21 StudentBig Brother 8 Joseph "Joe" Barber II23 Receptionist Michael "Mike" Dutz26 Painting contractor Nicholas "Nick" Starcevic25 Former football player Kail Harbick37 Business owner Dustin Erikstrup22 Shoe salesman Jennifer "Jen" Marie Johnson23 Nanny Amber M. Siyavus27 Cocktail waitress Jessica Lynn Hughbanks21 College student Eric Scott Stein27 Talent management assistant Jameka Cameron28 School counselor Zachary "Zach" Swerdzewski30 Graphic designer Daniele Donato20 Waitress Dick Donato44 Bar manager Jacob Heald23 ElectricianBig Brother 9 Neil Garcia29 Real estate agent Parker Somerville26 Paparazzo Jen Diturno26 Bartender Amanda Hansen23 Paralegal Alexander "Alex" Coladonato24 DJ company owner Allison Nichols28 Pharmaceutical sales representative Matthew "Matt" McDonald23 Roofing foreman Chelsia Hart21 College student Joshuah Welch25 Advertising media buyer James Zinkand21 Riding bicycle around the world Natalie Lynn Cunial28 Bikini barista Sharon Obermueller23 Real estate agent Sheila Kennedy45 Former model Ryan Quicksall27 College student Adam Jasinski29 Public relations manager Brian Hart27 Telecommunications manager Steven Daigle35 Rodeo competitor Angie Swindell29 Pharmaceutical sales representative Jessie Godderz22 Professional bodybuilding, professional wrestler Libra Thompson31 Human resources representative April Dowling30 Higley, AZ Financial manager Michelle Costa28 Real estate agent Bryan Ollie27 Marketing sales representative Lorenza "Renny" Martyn53 Beauty salon owner Keesha Smith29 Waitress Jerry MacDonald75 Retired marketing executive and Marine Corps Robert "Memphis" Garrett25 Mixologist Dan Gheesling24 Catholic school teacher

Seasons 11–20 (2009–2018)