Mick O'Brien may refer to:
Mick O'Brien (boxer) (born 1954), Australian Olympic boxer Mick O'Brien (footballer, born 1893), Irish international football player Mick O'Brien (footballer, born 1979), English football player Mick O'Brien (musician) (born 1961), Irish musician Mickey O'Brien, English composer and musician
See also Michael O'Brien (disambiguation)