Current largest selling pharmaceuticals of global market The top ten best-selling pharmaceuticals of 2025. Sales in billion USD. +RankDrugMain indicationTrade nameSales1pembrolizumaboncologyKeytruda31.62tirzepatidediabetes, obesityMounjaro23.03semaglutidediabetes, obesityOzempic19.24dupilumabatopic dermatitisDupixent17.85risankizumabplaque psoriasisSkyrizi17.66apixabananticoagulantEliquis14.77daratumumabmultiple myelomaDarzalex14.48Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy14.39tirzepatidediabetes, obesityZepbound13.510semaglutidediabetes, obesityWegovy12.0
Historical largest selling pharmaceuticals
2020-2024
2024 The top ten best-selling pharmaceuticals of 2024. Sales in billion USD. RankDrugMain indicationTrade nameSales1pembrolizumaboncologyKeytruda29.52semaglutidediabetes, obesityOzempic17.53dupilumabatopic dermatitisDupixent14.14Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy13.45apixabananticoagulantEliquis13.36risankizumabplaque psoriasisSkyrizi11.77daratumumabmultiple myelomaDarzalex11.78tirzepatidediabetes, obesityMounjaro11.59ustekinumabpsoriasisStelara10.410elexacaftor/tezacaftor/ivacaftorcystic fibrosisTrikafta10.2
2023 The top ten best-selling pharmaceuticals of 2023. Sales in billion USD. RankDrugMain indicationTrade nameSales1pembrolizumaboncologyKeytruda25.02adalimumabrheumatoid arthritisHumira14.43semaglutidediabetes, obesityOzempic13.94apixabananticoagulantEliquis12.25Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy11.96dupilumabatopic dermatitisDupixent11.67Pfizer–BioNTech COVID-19 vaccineCOVID-19 vaccinationComirnaty11.28ustekinumabpsoriasisStelara10.99daratumumabmultiple myelomaDarzalex9.710nivolumaboncologyOpdivo9.0
2022 The top ten best-selling pharmaceuticals of 2022. Sales in billion USD. RankDrugMain indicationTrade nameSales1Pfizer–BioNTech COVID-19 vaccineCOVID-19 vaccinationComirnaty40.82Moderna COVID-19 vaccineCOVID-19 vaccinationSpikevax21.83adalimumabrheumatoid arthritisHumira21.64pembrolizumaboncologyKeytruda21.05nirmatrelvir/ritonavirCOVID-19Paxlovid19.06apixabananticoagulantEliquis11.87Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy10.48afliberceptmacular degeneration, colorectal cancerEylea10.39ustekinumabpsoriasisStelara10.110lenalidomideoncologyRevlimid10.0
2021 The top ten best-selling pharmaceuticals of 2021. Sales in billion USD. RankDrugMain indicationTrade nameSales1Pfizer–BioNTech COVID-19 vaccineCOVID-19 vaccinationComirnaty36.92adalimumabrheumatoid arthritisHumira20.73Moderna COVID-19 vaccineCOVID-19 vaccinationSpikevax17.74pembrolizumaboncologyKeytruda17.25lenalidomideoncologyRevlimid12.86apixabananticoagulantEliquis10.87ustekinumabpsoriasisStelara9.18Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy8.69nivolumaboncologyOpvido7.610dulaglutidediabetesTrulicity6.5
2020 The top ten best-selling pharmaceuticals of 2020. Sales in billion USD. RankDrugMain indicationTrade nameSales1adalimumabrheumatoid arthritisHumira20.42pembrolizumaboncologyKeytruda14.43lenalidomideoncologyRevlimid12.24apixabananticoagulantEliquis9.25afliberceptmacular degeneration, colorectal cancerEylea8.46ustekinumabpsoriasisStelara7.97nivolumaboncologyOpvido7.98ibrutiniboncologyImbruvica7.69Bictegravir/emtricitabine/ tenofovir alafenamideHIV/AIDSBiktarvy7.310rivaroxabananticoagulantXarelto6.9
2012-2019 Top five best-selling pharmaceuticals 2012-2019.
2019 Source: adalimumab pembrolizumab lenalidomide apixaban nivolumab
2018 Source: adalimumab lenalidomide pembrolizumab trastuzumab bevacizumab
2017 Source: adalimumab lenalidomide rituximab trastuzumab bevacizumab
2016 Source: adalimumab ledipasvir etanercept rituximab infliximab
2015 Source: adalimumab ledipasvir etanercept infliximab rituximab
2014 Source: adalimumab sofosbuvir infliximab rituximab etanercept
2013 Source:Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014 aripiprazole adalimumab esomeprazole rosuvastatin etanercept
2012 Source: adalimumab infliximab etanercept fluticasone/salmeterol rituximab
2000-2011 Cumulative top ten best-selling pharmaceuticals between 2000 and 2011. Sales in billion USD RankDrugMain indicationTrade nameSales1atorvastatincholesterolLipitor121.42clopidogrelheart diseasePlavix74.63fluticasone/salmeterolasthmaAdvair58.84olanzapineschizophrenia, bipolar disorderZyprexa50.45etanerceptrheumatoid arthritisEnbrel45.26esomeprazolegastrointestinal disordersNexium44.37montelukastasthmaSingulair38.57quetiapine fumarateschizophrenia, bipolar disorderSeroquel36.79enoxaparinanticoagulantLovenox33.110adalimumabrheumatoid arthritisHumira32.0
See also List of drugs Lists about the pharmaceutical industry
References