HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology + DR15, DR2 and other serotype recognition of some DRB1*15 allelesderived from IMGT/HLA DRB1* DR15 DR2 DR16 Sample allele % % % size (N) 15:01 76 23 6428 15:02 77 16 676 15:03 81 13 286 15:04 >50 1 15:05 >25 2 15:07 >50 1 . DR16 DR2 DR15 N 16:01 41 29 19 703 16:02 47 30 16 239 16:04 >50 1
Disease associations DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis, narcolepsy, tuberculoid leprosy (multi-drug-resistant tuberculosis or leprosy), ulcerative colitis (Japanese), primary biliary cirrhosis and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.
Genetic linkage DR2 is linked to the HLA-DR51.
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