HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.
Serology + DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 allelesderived from IMGT/HLA DRB1* DR11 DR5 DR12 Sample allele % % % size (N) 11:01 92 5 3474 11:02 89 3 430 11:03 89 4 397 11:04 87 4 2119 11:05 75 4 11:06 20 73 15 11:07 >50 1 11:08 >50 2 11:09 80 20 5 . DR12 DR5 DR11 Sample 12:01 83 4 2 893 DR8 - 2% 12:02 89 162 12:03 >50 3 12:06 >50 2
Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.
Disease associations DR5 is associated with persistent generalized lymphadenopathy and Kaposi's sarcoma in AIDS, juvenile rheumatoid arthritis, pernicious anemia, Hashimoto's thyroiditis, mycosis fungoides, polyglandular deficiency syndrome, systemic sclerosis, childhood epilepsy, early-onset alopecia areata, short-ragweed Ra6 allergy, primary antiphospholipid syndrome, and increased longevity in the Dutch.
Genetic linkage HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).
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