major histocompatibility complex, class II, DR10 Haplotypes groups DQA*01:DRB1*1001 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1001 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1001 Shared data Locus chr.6 6p21.31
HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.
Serology + DR10 serotype recognition of the DRB1*1001 allele gene productderived from IMGT/HLA DRB1* DR10 DR1 Sample allele % % % size (N) 1001 90 4 894
The serological reaction of DR10 is relatively good.
Disease associations
By serotype DR10 serotype or cognate alleles are associated with: Lichen planus
By allele DRB1*1001 is associated with ovarian cancer and invasive squamous cell cervical cancer (SCC)
Extended linkage DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis The primary involvement appears to be DR10.
Genetic Linkage DR10 Haplotypes DRA DRB1 Haplotypes *0101 *1001 DQA1 DQB1 DRB1 Haplotypes *0101 *0501 *1001 HLA-A HLA-B DRB1 Haplotypes *0000 *0000 *1001
HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.
References