major histocompatibility complex, class II, DR14 Haplotypes groups DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1401 to *1408 *1410 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1401 EBI-HLA DRB1*1402 EBI-HLA DRB1*1403 EBI-HLA DRB1*1404 EBI-HLA DRB1*1405 EBI-HLA DRB1*1406 Shared data Locus chr.6 6p21.31
HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.
Alleles + DR14, DR6 and other serotype recognition of some DRB1*14 allelesderived from IMGT/HLA DRB1* DR14 DR6 DR13 Sample allele % % % size (N) 1401 74 14 3 1942 1402 61 13 9 204 1403 72 12 2 37 1404 79 8 80DR1404 - 3% 1405 86 10 58 1406 37 15 22 117 1407 90 10 1408 25 4 DR4 - 25% 1410 >75 4
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
Disease associations DRB1*1402: juvenile rheumatoid arthritis, increased longevity in Okinawans.
Extended linkage DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.
Genetic Linkage DR14 Haplotypes DRA DRB1 DRB3 DR14(6)-DR52 *0101 *1401 *0201 *0101 *1402 *0201 *0101 *1403 *0101 DQA1 DQB1 DRB1 DR14-DQ5(5.3, 1) *0104 *0503 *1401 HLA-A HLA-B DRB1 A11-B35-DR14(6) *1101 *3501 *1401 A2-B51(5)-DR14(6) *0201 *5101 *1401
HLA-DR13 is genetically linked to HLA-DR52 and HLA-DQ5 (HLA-DQ1) serotypes.
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