major histocompatibility complex, class II, DR13 Haplotypes groups DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 .... Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *1301 to *1308 *1310 Symbol(s) HLA-DRB1 EBI-HLA DRB1*1301 EBI-HLA DRB1*1302 EBI-HLA DRB1*1304 EBI-HLA DRB1*1306 EBI-HLA DRB1*1307 EBI-HLA DRB1*1310 Shared data Locus chr.6 6p21.31
HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.
Alleles + DR13, DR6 and other serotype recognition of some DRB1*13 allelesderived from IMGT/HLA DRB1* DR13 DR6 DR14 Sample allele % % % size (N) 1301 81 14 1 3788 1302 74 17 2 3081 1303 69 10 2 948DR12 - 3%, DR11 - 3% DR5-2% 1304 87 127 1305 54 12 305DR12 - 6%, DR11 - 7% DR5-4% 1306 78 9 1307 >50 1 1308 45 55 9 1310 >75 5
Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379 DRB1*13 allele group 81 Alleles: 74 proteins DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314 DR6 (weak DR13) Serotype: *1308 DR13&Other serotypes: *1303, *1305, *1311, Serotype unknown: *1309, *1315 to *1374
Disease associations DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.
Extended linkage DRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis
Genetic Linkage DR13 Haplotypes DRA DRB1 DRB3 DR13(6)-DR52 *0101 *1301 *0101 *0101 *1301 *0201 *0101 *1302 *0301 DQA1 DQB1 DRB1 DR13(6)-DQ6(6.3, 1) *0103 *0603 *1301 DR13(6)-DQ6(6.4, 1) *0102 *0604 *1302 DR13(6)-DQ6(6.5, 1) *0102 *0605 *1302 DR13(6)-DQ6(6.9, 1) *0102 *0609 *1302 HLA-A HLA-B DRB1 A2-Cw5-B44(16)-DR13 *02 *4402 *1301
HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) serotypes.
References