major histocompatibility complex, class II, DR17 Haplotypes groups DRA*01:DRB1*0301 DRA*01:DRB1*0304 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *0301 *0304 Symbol(s) HLA-DRB1 EBI-HLA DRB1*0301 EBI-HLA DRB1*0304 Shared data Locus chr.6 6p21.31
HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.
Serology + DR17 and DR3 recognition of some DRB1*03 allelesderived from IMGT/HLA DRB1* DR17 DR3 DR18 Sample allele % % % size (N) 0301 64 33 0 9698 0304 20 60 5
DR17 recognizes the DRB1*0301, *0304 alleles.
Disease associations
By serotype DR17 is associated with non-chronic sarcoidosis, infantile spasm/epilepsy, rabies vaccine-induced autoimmune encephalomyelitis and cardiovascular hypertrophy in subjects with arterial hypertension People with DR17 show a tendency toward benzylpenicilloyl allergies.
By allele DRB1*0301: diabetes mellitus type 1, myositis, early onset Graves disease, type 1 autoimmune hepatitis, inflammatory inclusion body myositis. In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease.
By haplotype DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis
By phenotype The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome
Genetic Linkage DR17 Haplotypes Serotypes DRA DRB1 DRB3 DR17 *0101 *0301 0101 *0101 *0301 0201 Serotypes DQA1 DQB1 DRB1 DR17(3)-DQ2(2.5) *0501 *0201 *0301 Serotypes HLA-A HLA C HLA B DRB1 A1-Cw7-B8-DR17(3) *0101 *0701 *0801 *0301 A2-Cw7-B8-DR17(3) *0201 *0701 *0801 *0301 A30-Cw5-B18-DR17(3) *3002 *0501 *1801 *0301
HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:
A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201
This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"
References