Mammillaria microthele is a species of flowering plant in the family Cactaceae. It is a succulent cactus subshrub endemic to northeastern Mexico. It grows under bushes in xerophytic shrubland (matorral), on hills and plains of the Mexican Plateau in the states of Coahuila, Nuevo León, San Luis Potosí, Tamaulipas, and Zacatecas.
Two subspecies are accepted: Mammillaria formosa subsp. formosa Mammillaria formosa subsp. microthele – southern Tamaulipas to north-central San Luis Potosí
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