River Knobs is a name applied to several terrain features in the eastern United States, including:
River Knobs, in Hawkins County, Tennessee River Knobs, in Hancock County, Tennessee River Knobs, in Rhea County, Tennessee River Knobs, in Roane County, Tennessee River Knobs, in Lee County, Virginia River Knobs, in Washington County, Virginia River Knobs (West Virginia), in Pendleton County, West Virginia