Twombly may refer to:

People Carol Twombly, American calligrapher Cy Twombly (1928–2011), American abstract artist Darren Twombly (born 1965), American football player Hamilton McKown Twombly, railroad tycoon, owner of Vinland Estate Mary Twombly (born 1935) American composer, conductor and pianist Timothy Twombly, American politician Voltaire P. Twombly, recipient of the Medal of Honor Wells Twombly (1935–1977), American sportswriter and author

Other uses Twombly Ridge, Maine, an unorganized area in the United States Twombly (cyclecar), an American automobile manufactured between 1913 and 1915 Bell Atlantic Corp. v. Twombly, a United States Supreme Court case

See also Twemlow, the Cheshire parish the name Twombly derives from Twemlow (surname)