P27 may refer to:
CDKN1B, cyclin-dependent kinase inhibitor 1B ČZ vz. 27, a pistol IFI27, interferon alpha-inducible protein 27 Papyrus 27, a biblical manuscript Phosphorus-27, an isotope of phosphorus Pixley Airport, in Tulare County, California, United States Projekt-27, an intelligence-gathering unit of the Swiss Armed Forces