RLI may refer to:
Organizations RLI Corp., an American property and casualty insurance company Rand Light Infantry, South Africa Renaissance Learning, an educational assessment and learning analytics company Rhodesian Light Infantry, military unit inside the Rhodesian army Royal Lancaster Infirmary, a hospital in Lancaster, England Rugby League Ireland
Other uses RLI (gene), also known as ABCE1, a protein required for translation initiation in eukaryotes RLi, an abbreviation for an organolithium reagent Red List Index, an indicator of global biodiversity