Bosisio is an Italian surname. Notable people with the surname include:
Franco Bosisio (born 1960), known as Franko B, Italian performance artist Gabriele Bosisio (born 1980), Italian cyclist Liù Bosisio (born 1936), Italian actress and playwright Lorenzo Bosisio (born 1944), Italian cyclist Marco Bosisio (born 2002), Italian footballer Renato Giuseppe Bosisio (1930–2019), Canadian engineer and academic.
See also Bosisio Parini, comune in Lombardy, Italy Brazilian frigate Bosísio (F48)