Epworth originally referred to Epworth, Lincolnshire, a town in England that was the birthplace of John Wesley and Charles Wesley, early leaders of the Methodist religious movement. The town's name has since been used for other places and institutions affiliated with the Methodist denomination of Christianity.

In addition to the English town, Epworth may refer to:

Places Canada Epworth, Newfoundland and Labrador, a hamlet, Burin Peninsula, Newfoundland Epworth Park, a neighborhood in Grand Bay-Westfield, New Brunswick

United States Epworth, Georgia, an unincorporated community Epworth by the Sea, Georgia, a Methodist retreat center Epworth, Illinois, a town Epworth, Iowa, a town near Dubuque Epworth, Missouri, an unincorporated community Epworth Heights, Michigan, a summer resort in Ludington, Michigan Epworth, Virginia, an unincorporated community

Zimbabwe Epworth, Zimbabwe, a city and suburb of Harare Epworth (constituency), a constituency of the Zimbabwean parliament

Buildings Epworth Hall (disambiguation), several buildings Epworth Hospital in Melbourne, Australia Epworth Military Academy (1857–1928), a defunct military academy in Epworth, Iowa Epworth School, a private school in Scottsville, Pietermaritzburg, KwaZulu-Natal, South Africa Epworth School (Epworth, Iowa) (1917–2011), a Colonial Revival/Romanesque Revival building in Epworth, Iowa, United States

Other uses Epworth League, a youth organization of the American Methodist Episcopal church Epworth sleepiness scale, used in the diagnosis of sleep apnea Friar Lane & Epworth F.C., a football (soccer) club, Aylestone, Leicestershire, England Epworth a tune written by Charles Wesley 1757-1834 to the hymn 'Forgive our sins as we forgive' (New English Hymnal 66); Epworth, Lincolnshire being his birthplace.