OSC may refer to:
Organizations Odborové sdružení československé, the Czechoslovak Trade Union Association Office of Special Counsel (in the United States of America) Ohio Supercomputer Center, a computing research facility in Columbus Ontario Science Centre, a science museum in Toronto, Canada Ontario Securities Commission, a securities regulatory agency Open Source Center, a United States government center that provides analysis of open-source intelligence Orbital Sciences Corporation, a satellite-oriented company Order of Saint Clare, a Religious Order founded by Clare of Assisi whose members use the post-nominal letters O.S.C. Ordo Sanctae Crucis or Canons Regular of the Order of the Holy Cross, a Roman Catholic religious order commonly called Crosiers Orlando Science Center, a science-education establishment in Florida Overseas School of Colombo, a multinational English medium international school located in Colombo, Sri Lanka.
Computing Open Sound Control, a music-oriented electronic communications protocol used in computers and multimedia devices openSUSE Command-line tool, a command-line tool used for openSUSE build service Orthogonal signal correction, a spectral preprocessing technique Operating system command, one of the C0 and C1 control codes Optical Signature Code, an industry standard format for LWIR signatures.
Other uses Off-site construction, a mode of construction Orson Scott Card (born 1951), American speculative-fiction author Organic solar cell Oscoda–Wurtsmith Airport (IATA code: OSC), Michigan, United States Osceola (Amtrak station) (Amtrak station code: OSC), Iowa, United States Order to show cause Object show community, the fandom for the genre started by the animated web series Battle for Dream Island