Mikołaj Sapieha may refer to several nobles from the Sapieha family:
Mikołaj Sapieha (died 1599) (before 1545 – 1599), voivode of Minsk, Brest Litovsk, Vitebsk
Mikołaj Sapieha (1581–1644), known as "Pious", voivode of Minsk, Brest Litovsk Mikołaj Sapieha (1588–1638), voivode of Minsk, Nowogrodek Mikołaj Krzysztof Sapieha (1613–1639), Field Notary of Lithuania Mikołaj Leon Sapieha (1644–1685), voivode of Bratslav