HTH may refer to:

Transportation Handforth railway station, England, station code Hawthorne Industrial Airport, Nevada, US, IATA and FAA LID code Helitt Líneas Aéreas, a Spanish charter airline, ICAO code Heworth Interchange, Tyne and Wear Metro, England, station code

Science and technology Helix-turn-helix, a protein structural motif Homothorax, an arthropod gene

Other uses Hand-to-hand combat High Tech High (disambiguation) House to House Heart to Heart, an American Christian magazine