Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A (23-membered macrolide) and streptogramin B (depsipeptide). The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.
Members include: Quinupristin/dalfopristin, made by chemically modifying pristinamycin (semisynthesis) Pristinamycin, made by Streptomyces pristinaespiralis Virginiamycin, made by Streptomyces virginiae and others Linopristin/flopristin, made by semisynthesis. experimental streptogramin in clinical trials for the treatment of respiratory tract infections. Etamycin, a streptogramin B.
References
Further reading