Hyperolius quadratomaculatus is a species of frog in the family Hyperoliidae. It is endemic to Mohorro, Tanzania. Its natural habitats are rivers, freshwater marshes, and intermittent freshwater marshes. It presumably breeds in waterbodies and has a larval development breeding strategy.
Distribution This species is endemic to Tanzania. Its type locality is the town of Mohorro in the Rufiji district of the Pwani region, but no wild populations are known.
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