Charlie or Charles Drake may refer to:
Actors Charles Drake (actor) (1917–1994), American actor Charlie Drake (1925–2006), English comedian, actor and singer Charlie Drake (TV series), British television comedy series
Military men Charles Drake (Garrard baronets) (1755–1817), English MP for Amersham, styled Charles Drake Garrard after inheriting estate Charles D. Drake (1811–1892), American senator from Missouri who served in U.S. Navy Charles Bryant Drake (1872–1956), American brigadier who served in Philippines Charles C. Drake (1887–1984), American brigadier in World War I and II
Others Charles George Drake (1920–1998), Canadian neurosurgeon Charles L. Drake (1924–1997), American geologist Charles Drake (American football) (1981–2012), safety for NFL and NFL Europe
Characters Charles Drake (Pretty Little Liars), gender reassigned villain known as Charlotte Drake