Spokane is a city in the state of Washington, United States.

Spokane may also refer to:

Places Spokane River, a tributary of the Columbia River Spokane Valley, of the Spokane River Spokane, Louisiana Spokane, Missouri Spokane, South Dakota, ghost town Spokane County, Washington

Other uses Spokane (film) Spokane (horse), winner of the 1889 Kentucky Derby Spokane people MV Spokane, a ferry operated Washington State Ferries Spokane Trophy, awarded by Commander United States Pacific Fleet , a Juneau-class light cruiser