The Great Plains is a large, flat region of land in North America.
Great Plains may also refer to:
Music Great Plains (Ohio band), a 1980s folk pop band Great Plains (Tennessee band), a progressive country pop band that formed in 1987 "The Great Plains", a song by Scale the Summit from the 2009 album Carving Desert Canyons
Other uses Great Plains Aircraft Supply Company, an American company Great Plains Airlines, a defunct airline Great Plains Software, an American software company sold to Microsoft Great Plains, a clothing brand of French Connection
See also Great Hungarian Plain, a plain occupying the majority of the modern territory of Hungary