The Sfântu Gheorghe branch (; ) is a distributary of the river Danube, that contributes in forming the Danube Delta.
This is the southernmost branch of the Danube; the other two main branches are the Chilia branch and the Sulina branch. The Sfântu Gheorghe branch runs on a length of , in a southeasterly direction. Its outflow comprises about 22% of the Danube's discharge.