HMS Nassau was a 64-gun third rate ship of the line of the Royal Navy, launched on 28 September 1785 by Hilhouse in Bristol.

One of her first ship's surgeons is thought to be John Sylvester Hay. He died young but he was the father of the actress Harriett Litchfield.K. A. Crouch, ‘Litchfield, Harriett (1777–1854)’, Oxford Dictionary of National Biography, Oxford University Press, 2004; online edn, Jan 2008 accessed 1 Feb 2015

During the Nore Mutiny she was commanded by Captain Edward O'Bryen. She was converted for use as a troopship in 1797.

Nassau was wrecked on the Kicks sandbar off Texel, the Netherlands, on 14 October 1799, there being 205 survivors and about 100 lives lost.The Reading Mercury and Oxford Gazette, 11 November 1799

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