Piranesi is an Italian surname. Notable people with the surname include:
Giovanni Battista Piranesi (1720–1778), Italian artist Francesco Piranesi (1758/59–1810), Italian engraver and architect, son of Giovanni Battista Piranesi Laura Piranesi (1754–1790), Italian etcher, daughter of Giovanni Battista Piranesi
Other uses Piranesi (software), architectural visualisation software by Informatix Software Piranesi (novel), a 2020 novel by Susanna Clarke