Matairesinol is an organic compound. It is classified as a lignan, i.e., a type of phenylpropanoid. It is present in some cereals, such as rye, and together with secoisolariciresinol has attracted much attention for its beneficial nutritional effects.

Metabolism The plant lignans are precursors of the enterolignans (mammalian lignans).

Biomedical considerations Although some studies attribute disease preventative (cardio-protective and hormone associated cancers like breast cancer) benefits of lignans, the results are inconclusive.Linus Pauling Institute at Oregon State University Matairesinol has been found to act as an agonist of the adiponectin receptor 1 (AdipoR1).

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