X22 may refer to:

X22 (New York City bus) Bell X-22, an American experimental aircraft Kh-22 (), a Soviet anti-ship missile Paul Magriel (1946–2018), American professional backgammon and poker player TGOJ X22, a Swedish electric multiple unit ThinkPad X22, a notebook computer \x22, the quotation mark (Unicode codepoint hex &x22;)

See also General Aircraft Hotspur X.22/40; military glider