Two-Headed Giant is the title of a multi-player format for the Magic: The Gathering trading card game.

Two-headed giant is also the title or description of a number of characters from legend and fiction: Boola in the Popeye the Sailor Meets Sindbad the Sailor cartoon short film The ettin in the Dungeons & Dragons role-playing game The ettin in the Three Thieves graphic novel series Gregor and Dane in the Kings of the Wyld fantasy novel Pire in The Chronicles of Narnia novel series Thunderdell, a two-headed giant from Cornwall appearing the story Jack the Giant Killer Two-Headed Giant in My Knight and Me TV series Two-Headed Giant in the Popeye and Son TV series Two-Headed Giant, an animated short film by Terrytoons A two-headed giant appears in the Adventures of Gilla Na Chreck An Gour Iris fairy tale A two-headed giant appears in the Garfield and Friends television series A two-headed giant appears in "Stupid Marco", a short story in The Practical Princess and Other Liberating Fairy Tales Two-headed giants appear in European folklore