Grigoriadis or Gregoriades () is a Greek surname, deriving from the given name Grigorios (Gregory). The feminine form is Grigoriadi (Γρηγοριάδη) or Grigoriadou/Gregoriadou (Γρηγοριάδου). Notable people with the surname include:
Afroditi Grigoriadou (1931–2020), Greek actress Aristeidis Grigoriadis (born 1985), Greek swimmer Elpida Grigoriadou (born 1971), Greek rower Gregory Gregoriadis (1934–2026), Greek biochemist Mary Grigoriadis (born 1942), American artist Michail Grigoriadis, Ottoman Greek official, Prince of Samos Neokosmos Grigoriadis (1879–1967), Greek general and politician Solon Grigoriadis (1912–1994), Greek naval officer, journalist, and politician Vanessa Grigoriadis, American journalist