Papadimitriou or Papademetriou () is a Greek surname that may refer to:
Alexandros Papadimitriou (born 1973), Greek Olympic hammer thrower Babis Papadimitriou (born 1954), Greek journalist, news analyst, economist and commentator Christos Papadimitriou (born 1949), Greek computer scientist Dimitri B. Papadimitriou (born 1946), Greek economist Elsa Papadimitriou (1942–2022), Greek politician Justin Peter Papadimitriou (born 1977), Canadian drummer Lefteris Papadimitriou (fl. 21st century), Greek composer Lisa Papademetriou (born 1971), American author of young adult fiction Nicholas Papademetriou (fl. 21st century), Australian actor of Greek Cypriot descent Thodoros Papadimitriou (1931–2018), Greek sculptor