Sacasa is a surname. Notable people with the name include:
Benjamín Lacayo Sacasa (1893–1959), President of Nicaragua Guillermo Sevilla Sacasa (1908–1997), Nicaraguan ambassador to the United States Juan Bautista Sacasa (1874–1946), President of Nicaragua Olga Sacasa (born 1961), Nicaraguan track and road cyclist Roberto Sacasa (1840–1896), President of Nicaragua Roberto Aguirre-Sacasa (born 1973), American playwright, screenwriter, and comic book writer
See also Anselmo Sacasas (1912–1998), Cuban jazz pianist, bandleader, composer, and arranger